The Spanish Football Federation (RFEF) said that Casico has been postponed between Barcelona and Real Madrid due to protests in Catalonia.
Clubs have until Monday morning to find a new date, which will be decided by the RFEF if the club cannot reach an agreement.
The original fixture was scheduled to take place at Bark's Camp Nou on 26 October.
"FC Barcelona and Real Madrid must agree on a new date of meeting before 21 October," an RFC statement said. "In the event of no agreement being reached, the Competition Committee will be responsible for setting the date of the meeting."
The Spanish Football League (LFP) said on Wednesday that it asked the RFEF to move the fixture from Barcelona to Madrid after three days of big demonstrations, which have become increasingly violent.