Pace Duo Mohammed Shami and Umesh Yadav gave India victory on the series whitewash after giving South Africa a follow-on in the third Test, as batsman Dean Elgar suffered an injury after being knocked out of the helmet.
At the end of the third day, the tourists were 132-8, trailing India by 203 runs, with batsman Thunis de Bruyn in 30 and Enrique Narje on five.
Opener Elgar hit a brilliant four at the helmet off short Yadav and was injured for 16 runs.
The opener was shaken as he lay on the ground to get the help of the physio.
South Africa said late Monday that Elgar was "evaluated and concluded by the team's medical staff".
The team said in a statement, "The next batsman will be closely monitored over the next 24 hours, recalculated every 24 hours until the signs and symptoms are resolved." Concussion protocol.
The events did not improve for South Africa, however, with Shami claiming three wickets, with South Africa captain Faf du Plessis taking four while Yadav struck twice.
In South Africa's first innings, top scorer Jubera Hamza indicated that his teammates were too focused on India's spin threat and were surprised by the fast bowlers.
Hamza said, "I would say that based on the general idea of playing in India, you believe it will be difficult to play against the spinners." "We will not say that we are ready against the sewer. I would just say that perhaps we should have been more mentally prepared in terms of playing in the situations we were facing."
South Africa's first innings ended on 162 runs when they declared India's 497-9.
The hosts got him batting again and Yadav released the first blood, left-handed Quinton de Kock – who were encouraged to open one of the five innings.
Shami got the first innings hero Hamza caught out as a bowler that uprooted his stump.
Spearhead then found du Plessis' prized skull and Temba Bavuma was caught on the back of a duck.
Spinners Ravindra Jadeja and Ravichandran Ashwin also took one wicket each to extend the final session, but De Bruyne and Nortje survived the final overs.
India's wicketkeeper Wriddhiman Saha suffered a finger injury in the final session and was handled by Rishabh Pant. According to new rules that allow a sub-division, a team is also allowed to replace a wicket-keeper.
Shahbaz Nadeem, who made his debut at the age of 30, also took two wickets with his left-arm spin, claiming that playing for the national team was a "dream" after taking 424 first-class scallops in the Indian domestic competition.
Hamza, playing his second Test, was happy to score a half-century in his first Test, presenting some resistance during the 91-run fourth wicket with Bavuma, who scored 32 runs.
"But also disappointed in the same breath, not running to use that opportunity," he said.
This is the first time I have been out twice in a single day, so it has been a difficult day. Really disappointing for the side. "
Opener Rohit Sharma handed India the command of the match with his first Test double century on Sunday. He made 212.
India won the first two Tests by a big margin in Visakhapatnam and Pune.